The F-16E Block 60 features an enormous amount of new capabilities. For one thing, the Fighting Falcon Block 60's range is extended with addition of fuselage mounted conformal fuel tanks and wing tanks, similar to the F-16ES and Block 50/52 Plus.

Secondly, the Northrop Grumman AN/ASQ-28 IFTS (Internal FLIR and Targeting System) replaces the pods in earlier aircraft. With state-of-the art components and packaging technology, the Internal FLIR Targeting System (IFTS) incorporates an advanced multi-functional FLIR/laser system into the F-16 nose to improve lethality and survivability with lower weight and drag and a laser targeting pod mounted underneath the fuselage. The elimination of bulky pods also enhances stealthiness.

Thirdly, there is an integrated electronic warfare suite with the Northrop Grumman 'Falcon Edge' internal electronic countermeasures system, the Northrop Grumman AN/APG-80 "Agile Beam Radar" with AESA (Active Electronically Scanned Array), an electronic warfare management system, fiber-optic avionics data bus and up to eight chaff/flare dispensers, as well as advanced friend or foe. The aircraft's advanced avionics suite has room available for future improvements. The Block 60's modular mission computer has a processing throughput of 12.5 million instructions per second and provides sensor and weapons integration.